T-cell switch

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

An inducible caspase 9 safety switch for T-cell therapy.

The efficacy of adoptive T-cell therapy as treatment for malignancies may be enhanced by genetic modification of infused cells. However, oncogenic events due to vector/transgene integration, and toxicities due to the infused cells themselves, have tempered enthusiasm. A safe and efficient means of removing aberrant cells in vivo would ameliorate these concerns. We describe a "safety switch" tha...

متن کامل

T CELL REGULATION OF THE Ig CLASS SWITCH

Signals from thymus-processed T cells are important in determining the quantities of various immunoglobul in (Ig) classes of ant ibody (Ab) 1 synthesized in response to antigen (1-6). We have recently reported that T cells can preferentially enhance the production of certain IgG isotypes, namely IgG2a, in the B cell response to the type 2 T-independent (TI-2) antigen, 2 trinitrophenyl (TNP)-Fic...

متن کامل

Switch Source End System Forward RM Cell Backward RM Cell Data Cell Switch Destination End System

The Available Bit Rate ABR service that is being standardized by the ATM Forum dynamically deter mines the maximum transmission rate the explicit rate of a connection A drawback of the dynamic control scheme for calculating the explicit rates is that it tries to allocate the same bandwidth to all ABR connections regardless of the application type of the connection In this study a multi level ex...

متن کامل

Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies.

Chimeric antigen receptor T (CAR-T) cell therapy has produced impressive results in clinical trials for B-cell malignancies. However, safety concerns related to the inability to control CAR-T cells once infused into the patient remain a significant challenge. Here we report the engineering of recombinant antibody-based bifunctional switches that consist of a tumor antigen-specific Fab molecule ...

متن کامل

Sulfamethoxazole Induces a Switch Mechanism in T Cell Receptors Containing TCRVβ20-1, Altering pHLA Recognition

T cell receptors (TCR) containing Vβ20-1 have been implicated in a wide range of T cell mediated disease and allergic reactions, making it a target for understanding these. Mechanics of T cell receptors are largely unexplained by static structures available from x-ray crystallographic studies. A small number of molecular dynamic simulations have been conducted on TCR, however are currently lack...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Genome Biology

سال: 2002

ISSN: 1465-6906

DOI: 10.1186/gb-spotlight-20020711-01